Microwave-assisted synthesis and in vitro antibacterial activity of novel steroidal 1,2,4-triazole Schiff base derivatives

作者：Wang Xiaohong; Liu Xingli; Jiang Yujia; Zhao Zhigang^*

来源：Journal of Chemical Research, 2014, 38(5): 300-303.

DOI：10.3184/174751914X13969706967486

• 1,2,4-triazole
• Schiff base
• deoxycholic acid
• microwave irradiation
• antibacterial activity

A series of novel Schiff bases containing both a 1,2,4-triazole and deoxycholic acid skeleton have been synthesised in excellent yields and in high purity by means of microwave irradiation. The structures of the target compounds were characterised by MS, IR and NMR as well as elemental analysis. All the products were evaluated for their in vitro antibacterial activities against Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Pseudomonas seruginosa and Escherichia coli). Four of the compounds displayed varying levels of antibacterial activity against P. aeruginosa and S. aureus, but none of the compounds showed any activity against E. coli and B. subtilis.

• 出版日期2014-5
• 单位西南民族大学