摘要
In 2 patients with As(2)O(3)-refractory acute promyelocytic leukemia (APL), Goto et al identified missense mutations in the PML-region B2-box domain that neighbor the dicysteine motif recently found to be critical for PML-RAR alpha degradation, a requirement for curative anti-APL effect.(1)
- 出版日期2011-8-11