Mutants strike again in APL

作者:Gallagher Robert E*
来源:Blood, 2011, 118(6): 1432-1434.
DOI:10.1182/blood-2011-06-357566

摘要

In 2 patients with As(2)O(3)-refractory acute promyelocytic leukemia (APL), Goto et al identified missense mutations in the PML-region B2-box domain that neighbor the dicysteine motif recently found to be critical for PML-RAR alpha degradation, a requirement for curative anti-APL effect.(1)

  • 出版日期2011-8-11