Discovery of Novel Spiro[3H-indole-3,2 '-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction

Gollner Andreas; Rudolph Dorothea; Arnhof Heribert; Bauer Markus; Blake Sophia M; Boehmelt Guido; Cockroft Xiao Ling; Dahmann Georg; Ettmayer Peter; Gerstberger Thomas; Karolyi Oezguer Jale; Kessler Dirk; Kofink Christiane; Ramharter Juergen; Rinnenthal Joerg; Savchenko Alexander; Schnitzer Renate; Weinstabl Harald; Weyer Czernilofsky Ulrike; Wunberg Tobias; McConnell Darryl B

doi:10.1021/acs.jmedchem.6b00900

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Discovery of Novel Spiro[3H-indole-3,2 '-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction

作者：Gollner Andreas; Rudolph Dorothea; Arnhof Heribert; Bauer Markus; Blake Sophia M; Boehmelt Guido; Cockroft Xiao Ling; Dahmann Georg; Ettmayer Peter; Gerstberger Thomas; Karolyi Oezguer Jale; Kessler Dirk; Kofink Christiane; Ramharter Juergen; Rinnenthal Joerg; Savchenko Alexander; Schnitzer Renate; Weinstabl Harald; Weyer Czernilofsky Ulrike; Wunberg Tobias; McConnell Darryl B

来源：Journal of Medicinal Chemistry, 2016, 59(22): 10147-10162.

DOI：10.1021/acs.jmedchem.6b00900