Assessment of antinociceptive, anti-inflammatory and antioxidant properties of Cymbopogon winterianus leaf essential oil

作者：Leite Barbara L S; Bonfim Rangel R; Antoniolli Angelo R; Thomazzi Sara M; Araujo Adriano A S; Blank Arie F; Estevam Charles S; Cambui Erica V F; Bonjardim Leonardo R; Albuquerque Junior Ricardo L C; Quintans Junior Lucindo J

来源：Pharmaceutical Biology, 2010, 48(10): 1164-1169.

DOI：10.3109/13880200903280000

• Cymbopogon winterianus
• essential oil
• antinociceptive
• anti-inflammatory
• antioxidant

The present study investigated the antinociceptive, anti-inflammatory and antioxidant effects of the leaf essential oil (LEO) of Cymbopogon winterianus Jowitt (Poaceae). In the acetic acid-induced writhing and formalin tests, the LEO (50, 100, and 200 mg/kg, p.o.) significantly reduced (p < 0.05) the number of writhings and paw licking times in the first (0-5 min) and second (15-30 min) phases, respectively. In contrast, the LEO did not alter the latency time for mice licking the rear paws in hot-plate test. The LEO inhibited the carrageenan-induced neutrophil migration to the peritoneal cavity in a dose-dependent manner (35.5%, 42.8%, and 66.1% at doses of 50, 100, and 200 mg/kg, respectively, p < 0.001). Moreover, LEO exhibited higher scavenging activity toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with an IC50 (12.66 +/- 0.56 mu g/mL). Our present results demonstrated that the LEO has antinociceptive, anti-inflammatory, and antioxidant properties.

• 出版日期2010-10