A Case with Hodgkin Lymphoma and Fronto-temporal Lobular Degeneration (FTLD)-like Dementia Facilitated by Chemotherapy

作者：Katsumata Ryuta; Sagawa Ryuichi^*; Akechi Tatsuo; Shinagawa Yoshihiro; Nakaaki Syutaro; Inagaki Atsushi; Okuyama Toru; Akazawa Terukazu; Furukawa Toshiaki A

来源：Japanese Journal of Clinical Oncology, 2010, 40(4): 365-368.

DOI：10.1093/jjco/hyp170

• malignant lymphoma
• chemotherapy
• dementia
• cognitive dysfunction
• neuropsychiatric symptoms

We report a case of a 39-year-old man with Hodgkin lymphoma who developed depressive symptoms after starting adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy and later exhibited sexual disinhibition in addition to cognitive dysmainly executive dysfunction). Seven months after the start of adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy, he was finally diagnosed as having fronto-temporal lobular degeneration-like dementia facilitated by adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy. At the time of writing, the patient's condition has persisted for more than 6 months after the discontinuation of adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy, and the changes in brain function brought on by the adriamycin, bleomycin, vinblastine and dacarbazine chemotherapy may now be irreversible. This case points to the importance of being attentive to the appearance of neuropsychiatric symptoms and evaluating brain functions properly when performing anti-cancer chemotherapy.

• 出版日期2010-4