Mixed-Ligand Catalysts: A Powerful Tool in Transition-Metal-Catalyzed Cross-Coupling Reactions

作者：Fan Yuting; Cong Mei; Peng Ling^*

来源：Chemistry - A European Journal, 2014, 20(10): 2698-2702.

DOI：10.1002/chem.201304715

• chelates
• cross-coupling reactions
• homogenous catalysis
• mixed-ligand systems
• transition metals

Transition-metal-catalyzed cross-coupling reactions have fundamentally revolutionized organic synthesis, empowering the otherwise difficult to achieve products with rapid and convenient accesses alongside excellent yields. Within these reactions, ligands often play a critical role in specifically and effectively advocating the corresponding catalysis. Consequently, a myriad of ligands have been created and applied to make a fine tuning of electronic and steric effect of catalysts, remarkably promoting catalytic efficiency and applicability. The mixed-ligand concept has recently emerged; by combining and capitalizing on the superiority of each individual ligand already available, an expedient way can be achieved to reach a larger extent of catalytic diversity and efficacy. Given the availability of a wealth of ligands, it is reasonable to have great expectations for the original application of mixed-ligand catalytic systems and their important value in organic synthesis.

• 出版日期2014-3-3