Non-linear molecular pattern classification using molecular beacons with multiple targets

作者：Lee In Hee; Lee Seung Hwan; Park Tai Hyun; Zhang Byoung Tak^*

来源：Biosystems, 2013, 114(3): 206-213.

DOI：10.1016/j.biosystems.2013.05.008

• DNA computing
• Molecular pattern classification
• Non-linear classification
• Molecular beacons
• Biological data analysis

In vitro pattern classification has been highlighted as an important future application of DNA computing. Previous work has demonstrated the feasibility of linear classifiers using DNA-based molecular computing. However, complex tasks require non-linear classification capability. Here we design a molecular beacon that can interact with multiple targets and experimentally shows that its fluorescent signals form a complex radial-basis function, enabling it to be used as a building block for non-linear molecular classification in vitro. The proposed method was successfully applied to solving artificial and real-world classification problems: XOR and microRNA expression patterns.

• 出版日期2013-12