Dynamin-1-like protein (Dnm1L) interaction with kinesin light chain 1 (KLC1) through the tetratricopeptide repeat (TPR) domains

作者：Jang Won Hee; Jeong Young Joo; Choi Sun Hee; Kim Sang Jin; Urm Sang Hwa; Seog Dae Hyun^*

来源：Bioscience Biotechnology and Biochemistry, 2014, 78(12): 2069-2072.

DOI：10.1080/09168451.2014.943652

• TPR domain
• kinesin 1
• KLC1
• Dnm1L

Kinesin light chain 1 (KLC1) mediates binding of KIF5 motor to specific cargo. Using the yeast two-hybrid screening, we found that mitochondrial fission protein dynamin-1-like protein (Dnm1L) interacted with KLC1, but not KIF5. Dnm1L and KLC1 were co-localized in cultured cells. These results suggest that KLC1 may play a potential role in post-fission mitochondrial transport.

• 出版日期2014-12-2