Urinary quality of life after prostatectomy or radiation for localized prostate cancer: A prospective longitudinal cross-cultural study between Japanese and US men

作者：Narniki Shunichi; Kwan Lorna; Kagawa Singer Marjorie; Terai Akito; Arai Yoichi; Litwin Mark S^*

来源：Urology, 2008, 71(6): 1103-1108.

DOI：10.1016/j.urology.2008.02.025

OBJECTIVES To compare the evolution of urinary dysfunction and associated distress (bother) during the first 2 years after radical prostatectomy (RP) or external beam radiation therapy (EBRT) between Japanese and U.S. men with localized prostate cancer.
METHODS A total of 477 Japanese men and 385 U.S. men with localized prostate cancer who underwent RP or EBRT participated in paired longitudinal outcomes studies. We evaluated urinary control and distress using the University of California-Los Angeles, Prostate Cancer Index and urinary irritation/obstruction using the American Urological Association Symptom Index (AUASI) before and 1, 2 to 3, 4 to 6, 8, 12, 18, and 24 months after treatment. We used general linear mixed modeling adjusting for subject characteristics to assess changes in these domains.
RESULTS Multivariate analyses revealed a nonlinear trend of recovery and an interaction between this trend and country with regard to urinary control) and bother after RP (both P < 0.0001). Among the men who received EBRT, the recovery trend of AUASI and urinary,bother also differed significantly by country (both P < 0.0001).
CONCLUSIONS Japanese and U.S. men differed in their patterns of urinary recovery up to 24 months after curative therapy for localized prostate cancer.

• 出版日期2008-6