DEVELOPMENT AND CHARACTERIZATION OF LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION

作者：dos Santos Guilherme Soares^*; Pereira Gabriela Garrastazu; Bender Eduardo Andre; Colome Leticia Marques; Guterres Silvia Staniscuaski; Manhaes de Carvalho Daniel Canema; Weissmueller Gilberto

来源：Quimica Nova, 2012, 35(7): 1388-U530.

DOI：10.1590/S0100-40422012000700019

• lipid nanoparticles
• dapsone
• in vitro release study

DEVELOPMENT AND CHARACTERIZATION OF LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION. In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 +/- 1.6%) in comparison to the free drug (103.1 +/- 1.9%).

• 出版日期2012