An efficient route to coumarin derivatives under dual catalysis, an organo- and a Lewis acid catalyst

作者：Maiti Gourhari^*; Karmakar Rajiv; Kayal Utpal; Bhattacharya Rudraksha Nath

来源：Tetrahedron, 2012, 68(42): 8817-8822.

DOI：10.1016/j.tet.2012.07.092

• Dialkyl acetylenedicarboxylate
• o-Hydroxy aromatic aldehyde
• Dual catalysis
• Coumarin derivatives
• Iron(III)chloride

An efficient reaction of dialkyl acetylenedicarboxylate with various o-hydroxy aromatic aldehydes under dual catalysis with piperidine and FeCl3 in refluxing toluene afforded alkyl 2-oxo-2-(2-oxo-2H-chromen-3-yl) acetates in good to excellent yield. The advantages of this reaction include the use of easily available starting materials, one-pot reaction, mild reaction conditions and operational simplicity.

• 出版日期2012-10-21