Acute and chronic infections with nonprimate hepacivirus in young horses

作者：Gather Theresa; Walter Stephanie; Pfaender Stephanie; Todt Daniel; Feige Karsten; Steinmann Eike; Cavalleri Jessika M V

来源：Veterinary Research, 2016, 47(1): 97.

DOI：10.1186/s13567-016-0381-6

The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evaluated. The four young horses were not able to clear infection, but remained chronically infected for the entire monitored time period despite the presence of NPHV specific antibodies.

• 出版日期2016-9-22