科研之友
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摘要
Organocatalytic asymmetric additions of unmodified aldehydes to beta-nitrostyrenes are important carbon-carbon bond formation reactions and have become very attractive recently, because they are metal-free and environmentally benign. This work employed a series of L-proline-based diphenyl dipeptidols to catalyze this reaction. The results showed that these dipeptidols were effective organocatalysts with the yield up to 99%. 3a was optimal with the highest enantioselectivity up to 75% and dr (syn/anti) up to 94/6. In addition, the mechanism of this asymmetric reaction is also discussed.
- 出版日期2009-1
- 单位兰州大学
