A nor-diterpene from Salvia sahendica leaves

作者:Tabatabaei Sahar Mofidi; Salehi Peyman*; Farimani Mahdi Moridi; Neuburger Markus; De Mieri Maria; Hamburger Matthias; Nejad Ebrahimi Samad
来源:Natural Product Research, 2017, 31(15): 1758-1765.
DOI:10.1080/14786419.2017.1290619

摘要

Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), -sitosterol (4), salvigenin (5) and 3-hydroxy-11,12-epoxyoleanan-28,13-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli. [GRAPHICS] .

  • 出版日期2017