Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes

作者：Hong, Seong Su; Lee, Ji Hae; Jeong, Wonsik; Kim, Nahyun; Jin, Hui Zi; Hwang, Bang Yeon; Lee, Hak-Ju; Lee, Sung-Joon; Jang, Dae Sik^*; Lee, Dongho

来源：Bioorganic & Medicinal Chemistry Letters, 2012, 22(6): 2347-2349.

DOI：10.1016/j.bmcl.2012.01.070

• Chanterelle
• Cantharellus cibarius
• Peroxisome proliferator-activated receptor (PPAR)-gamma agonist
• Acetylenic acid

A new acetylenic acid, (10E, 14Z)-9-oxooctadeca-10,14-dien-12-ynoicacid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E, 14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-gamma with an EC50 value of 1.88 mu M as measured by a reporter gene assay. Expression of PPAR-gamma target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-gamma potential agonist that regulates transcription of the PPAR-gamma target genes.

• 出版日期2012-3-15
• 单位上海交通大学