Dynamic characteristics of heart rate control by the autonomic nervous system in rats

作者：Mizuno Masaki^*; Kawada Toru; Kamiya Atsunori; Miyamoto Tadayoshi; Shimizu Shuji; Shishido Toshiaki; Smith Scott A; Sugimachi Masaru

来源：Experimental Physiology, 2010, 95(9): 919-925.

DOI：10.1113/expphysiol.2010.053090

We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min-1 Hz-1; natural frequency, 0.07 +/- 0.03 Hz; damping coefficient, 1.96 +/- 0.64; and lag time, 0.73 +/- 0.12 s). The transfer function from vagal stimulation to HR response approximated a first-order, low-pass filter with a lag time (gain, 8.84 +/- 4.51 beats min-1 Hz-1; corner frequency, 0.12 +/- 0.06 Hz; and lag time, 0.12 +/- 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.

• 出版日期2010-9-1