Application of Trimethylsilanolate Alkali Salts in Organic Synthesis

作者：Burglova Kristyna; Hlavac Jan^*

来源：Synthesis (Germany), 2018, 50(6): 1199-1208.

DOI：10.1055/s-0037-1609202

• trimethylsilanolate
• ester hydrolysis
• cleavage
• alkali metals
• coupling promoter
• solid-phase chemistry
• synthesis

Trimethylsilanolate alkali salts are widely used in organic synthesis, mainly due to their solubility in common organic solvents. They are frequently used as nucleophiles in ester hydrolysis, both in solution and solid-phase chemistry. However, they have also been used as mild bases or as specific reagents in some chemical transformations. Reactions employing trimethylsilanolate alkali salts as the key component are typically performed under mild reaction conditions. This review summarizes the utilization of trimethylsilanolate alkali salts in various organic transformations. 1Introduction 2 Properties of Alkali Metal Trimethylsilanolates (TMSO[M]) 3 Trimethylsilanolate Alkali Salts in Organic Synthesis 4 Conclusion

• 出版日期2018-3