Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Nazarov A A<sup>*</sup>; Nosova Yu N; Mikhalev O V; Kovaleva O N; Dyson P J; Milaeva E R

doi:10.1007/s11172-016-1335-x

登录

免费注册

赞收藏引用

科研之友

微信

新浪微博

Facebook

分享链接

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

作者：Nazarov A A^*; Nosova Yu N; Mikhalev O V; Kovaleva O N; Dyson P J; Milaeva E R

来源：Russian Chemical Bulletin, 2016, 65(2): 546-549.

DOI：10.1007/s11172-016-1335-x

摘要

New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of new compounds against ovarian carcinoma cell cultures A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) are reported. The dependence of cytotoxicity on the number of phosphine ligands was demonstrated.