Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs

作者：Nandurdikar Rahul S^*; Maciag Anna E; Hong Sam Y; Chakrapani Harinath; Citro Michael L; Keefer Larry K; Saavedra Joseph E

来源：Organic Letters, 2010, 12(1): 56-59.

DOI：10.1021/ol902481s

GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bifunctionalize these PROLI/NO prodrugs, which on activation generate up to 4 mol of NO, a peptide residue, and an N-acetylglucosamine residue. Many of the prodrugs synthesized are efficient sources of intracellular NO.

• 出版日期2010-1-1