Measured resting energy expenditure is related to measures of bone in adult men

作者：Leavitt Torey C; Eggett Dennis L; Hancock Chad R; Fullmer Susan^*

来源：Obesity and Metabolism-Milan, 2010, 6(2-3): 80-85.

• Bone metabolism
• bone mineral density
• energy homeostasis
• energy metabolism
• fat mass
• resting energy expenditure

Background and aims: Bone has been shown to play a role in the regulation of energy metabolism. It has previously;men shown that predicted resting energy expenditure (REE), calculated by the Harris-Benedict equation, is a strong predictor of bone mineral density (BMD) in women. The purpose of this study was to investigate the relationship between measured REE and markers of bone in adult sedentary men. Methods: This observational study included 76 adult men (30-65 yr) divided into quartiles based on bone measurements. Body composition, BMD, bone mineral content (BMC) at the lumbar spine, hip and total body were assessed by dual energy x-ray absorptiometry. REE was measured via indirect calorimetry and then adjusted for body weight (REE/kg), fat mass (REE/FM) and lean body mass (REE/LBM). Osteocalcin (OC and C-terminal of collagen I (CTX-MMP) were measured as biomarkers of bone turnover Dietary intake was evaluated with a validated food frequency questionnaire. Height, weight, body mass index, waist-to-hip ratio, and serum leptin were also measured. Differences between quartile groups were determined using analysis of covariance (ANCOVA). Results: Results showed REE/kg was significantly related to spine BMC (p=0.0023) and hip BMC (p=0.0012) after adjusting for leptin as a covariate. REE/FM was significantly related to total body BMD (p=0.0073) and total body BMC (p=0.0024) with BMI, LBM/kg, and leptin as significant covariates. REE/LBM was not related to any measures of bone. OC and CTX-MMP were not related to any measures of REE. Dietary intake was not related to measurements of bone or REE. Conclusions: This study showed an association between measured REE and bone. Further research to clarify the nature of the relationship and mechanism(s) is warranted. Obesity and Metabolism 2010; 6: 80-85.

• 出版日期2010-9