Antioxidant flavone glycosides and other constituents from -Premna latifolia leaves

作者：Ghosh Partha Sarathi; Das Niranjan; Dinda Biswanath^*

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2014, 53(6): 746-749.

• Premna latifolia
• verbenaceae
• flavonoids
• antioxidant

A new flavone glycoside, apigenin 7-O-beta-D-apiofuranosyl (1 -> 2)-alpha-L-rhamnopyranoside 1 along with known compounds; apigenin 7-O-beta-D-glucopyranoside-4'-acetate 2 and beta-sitosterol-3-O-beta-D-glucoside 3 have been isolated from the MeOH extract of the leaves of the medicinal plant, Premna latifolia Roxb (Verbenaceae). The structure of the new compound 1 has been elucidated on the basis of detailed spectral (including 2D-NMR) and chemical (including transformations into hexa and hepta acetates) studies. The notations of sugars in 1 have been assigned on GC analysis of their TMS derivatives. The isolation of compound 2 is being reported for the first time from a higher plant. Both flavones 1 and 2 exhibit significant DPPH radical scavenging activity with IC50 value of 16.0 and 22.5 mu g/mL, respectively, which is comparable to that of standard antioxidant, BHT (IC50 of 17.5 mu g/mL). Hence, the MeOH extract of the leaves of this plant may be useful as a potential source of natural antioxidant.

• 出版日期2014-6