A macromolecular trafficking complex composed of beta(2)-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels

作者：Flynn Robyn; Altier Christophe^*

来源：Journal of Receptors and Signal Transduction, 2013, 33(3): 172-176.

DOI：10.3109/10799893.2013.782219

• AKAP
• L-types
• phosphorylation
• sympathetic modulation
• trafficking
• Voltage-gated calcium channels

Sympathetic modulation of cardiac L-type calcium channels is an important mechanism for regulating heart rate and cardiac contractility. At the molecular level, activation of beta-adrenergic receptors (beta AR) increases calcium influx into cardiac myocytes by activating protein kinase A (PKA), leading to subsequent phosphorylation of L-type calcium channels. In the case of the beta(2)AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta(2)AR complex. Our work has shown that, in addition to facilitating PKA phosphorylation of the channel, AKAPs also promote an increase in the Cav1.2 channel surface expression. Here we review the molecular mechanisms of beta(2)AR/AKAP/L-type channel interactions and trafficking.

• 出版日期2013-6