A simple modification of TG-43 based brachytherapy dosimetry with improved fitting functions: Application to the selectSeed source

作者：Juan Senabre Xavier J; Porras Ignacio^*; Lallena Antonio M

来源：Physica Medica, 2013, 29(4): 403-411.

DOI：10.1016/j.ejmp.2012.05.007

• TG-43
• I-125 brachytherapy sources
• Nucletron selectSeed
• Monte Carlo
• PENELOPE

A variation of TG-43 protocol for seeds with cylindrical symmetry aiming at a better description of the radial and anisotropy functions is proposed. The TG-43 two dimensional formalism is modified by introducing a new anisotropy function. Also new fitting functions that permit a more robust description of the radial and anisotropy functions than usual polynomials are studied. The relationship between the new anisotropy function and the anisotropy factor included in the one-dimensional TG-43 formalism is analyzed. The new formalism is tested for the I-125 Nucletron selectSeed brachytherapy source, using Monte Carlo simulations performed with PENELOPE. The goodness of the new parameterizations is discussed. The results obtained indicate that precise fits can be achieved, with a better description than that provided by previous parameterizations. Special care has been taken in the description and fitting of the anisotropy factor near the source. The modified formalism shows advantages with respect to the usual one in the description of the anisotropy functions. The new parameterizations obtained can be easily implemented in the clinical planning calculation systems, provided that the ratio between geometry factors is also modified according to the new dose rate expression.

• 出版日期2013-6