Optimizing vaccine-induced CD8(+) T-cell immunity: focus on recombinant adenovirus vectors

作者：Bassett Jennifer D; Swift Stephanie L; Bramson Jonathan L^*

来源：Expert Review of Vaccines, 2011, 10(9): 1307-1319.

DOI：10.1586/ERV.11.88

• antigen-presenting cell
• immunology
• memory CD8(+) T cell
• recombinant adenovirus vaccine
• T-cell polyfunctionality
• vaccine optimization

Recombinant adenoviruses have emerged as promising viral vectors for CD8(+) T-cell vaccines. Our studies have indicated that unlike most acute infections, the CD8(+) T-cell memory population elicited by recombinant human adenovirus serotype 5 (rHuAd5) displays a dominant effector memory phenotype. Persistent, low-level transgene expression from the rHuAd5 vector sustains the CD8(+) T-cell memory population and a nonhematopoietic cell compartment appears to be involved in long-term presentation of adenoviral antigens. Although we are beginning to learn more about the factors that control the maintenance and functionality of memory CD8(+) T cells, we do not yet fully understand what comprises a protective CD8(+) T-cell response. Results from upcoming Phase II clinical trials will be important for determining whether rHuAd5 T-cell vaccines are effective in humans and should help identify correlates of CD8(+) T-cell protection.

• 出版日期2011-9