Antinucleosome antibodies and primary antiphospholipid syndrome: an observational study

作者：Silva de Souza Alexandre Wagner; Keusseyan Silene Peres; da Silva Neusa Pereira; Sato Emilia Inoue; Coelho Andrade Luis Eduardo

来源：Revista Brasileira de Reumatologia, 2012, 52(3): 357-365.

• antiphospholipid syndrome
• systemic lupus erythematosus
• anticardiolipin antibodies
• lupus coagulation inhibitor nucleosomes

Objective: To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. Materials and methods: Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-NCS/chromatin antibodies. Results: After a mean follow-up period of 45.7 months, anti-NCS/chromatin antibodies were detected in only one patient (2.8%), who developed features of SLE including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profile suggestive of SLE. Conclusion: The frequency of anti-NCS/chromatin antibodies in primary APS patients is very low, and they may be associated with the development of SLE manifestations.

• 出版日期2012-6