Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

作者：Bruni Natascia; Capucchio Maria Teresa; Biasibetti Elena; Pessione Enrica; Cirrincione Simona; Giraudo Leonardo; Corona Antonio; Dosio Franco^*

来源：Molecules, 2016, 21(6): 752.

DOI：10.3390/molecules21060752

• antimicrobial peptides
• lactoferricin
• milk proteins
• food safety

Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1-11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein. Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases).

• 出版日期2016-6