A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.

作者：Motohashi Keiichiro; Takagi Motoki; Yamamura Hideki; Hayakawa Masayuki; Shin ya Kazuo^*

来源：Journal of Antibiotics, 2010, 63(9): 545-548.

DOI：10.1038/ja.2010.94

• angucycline
• antimicrobial activity
• butenolide
• cytotoxicity
• dichlorocyclopropane
• lichen
• Streptomyces

A new 1,1-dichlorocyclopropane-containing angucycline, JBIR-88 (1), and a new butenolide, JBIR-89 (2), respectively, were isolated from the fermentation broths of two lichen-derived actinomycetes identified as a new species of Streptomyces (strains RI104-LiC106 and RI104-LiB101) using phylogenetic methods. The structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compound 1 showed cytotoxic activities against cancer cells and antimicrobial activity against Micrococcus luteus. The Journal of Antibiotics (2010) 63, 545-548; doi:10.1038/ja.2010.94; published online 28 July 2010

• 出版日期2010-9