Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats

作者：Veeramani Chinnadurai; Al Numair Khalid S; Alsaif Mohammed A; Chandramohan Govindasamy; Al Numair Nouf S; Pugalendi Kodukkur Viswanathan^*

来源：Asian Pacific Journal of Tropical Medicine, 2012, 5(12): 939-944.

DOI：10.1016/S1995-7645(12)60178-3

• Streptozotocin
• Cardiospermum halicacabum leaf extract
• Hexose
• Hexosamine
• Fucose
• Sialic acid

OBJECTIVE: To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats. METHODS: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The C. halicacabum leaf extract (CHE) was administered orally to normal and STZ-diabetic rats for 45 days. The effects of C. halicacabum leaf extract (CHE) on plasma and tissue glycoproteins (hexose, hexosamine, fucose and sialic acid) were determined. RESULTS: The levels of plasma and tissues glycoproteins containing hexose, hexosamine and fucose were significantly increased in STZ-induced diabetic rats. In addition, the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats. After administration of CHE to diabetic rats, the metabolic alteration of glycoprotein reverted towards normal levels. CONCLUSIONS: The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.

• 出版日期2012-12