A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of beta-ketoesters as cleavable probes

作者:Qian Jiang; Wani Revati; Klomsiri Chananat; Poole Leslie B; Tsang Allen W; Furdui Cristina M*
来源:Chemical communications, 2012, 48(34): 4091-4093.
DOI:10.1039/c2cc17868k

摘要

beta-ketoesters are robust probes for labeling sulfenic acid (-SOH) proteins allowing quantitative cleavage of the tag for improved analysis of the labeled peptides by MS.

  • 出版日期2012