科研之友
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摘要
The simple, accurate and precise HPLC method for determination of Artesunate in bulk and tablet dosage form has been developed. Quantitation of drug was carried out on Jasco HPLC system with HiQ-SiL C(8) column (250 mm x 4.6 mm i.d.), using acetonitrile: 1 M sodium acetate buffer (pH 3 adjusted with o-phosphoric acid) in the ratio 70: 30 as mobile phase. Method was developed using Artemether as internal standard and UV detector set at 220 nm. Linear concentration range was found to be 250-2500 mu g/mL. The method has been successfully applied to the analysis of drugs in bulk and pharmaceutical formulation. The method was validated with respect to linearity, precision and accuracy as per the International Conference on Harmonisation guidelines.
- 出版日期2010-5
