A mimic of the pyruvate dehydrogenase complex

作者：Zhao Huanyu; Breslow Ronald^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(20): 5973-5975.

DOI：10.1016/j.bmcl.2010.08.077

• Heterocyclic carbene
• Oxidative metabolism
• Polymer catalysts

Pyruvic acid undergo decarboxylation catalyzed by a hydrophobic thiazolium salt and reacts with a hydrophobic analog of lipoic acid to form a hydrophobic acylthioester that reacts with aniline to form acetanilide in water, but only in the presence of a hydrophobically modified polyaziridine that acts to gather the reactants just as the enzyme complex does.

• 出版日期2010-10-15