A genome-wide association study of DSM-IV cannabis dependence

作者：Agrawal Arpana^*; Lynskey Michael T; Hinrichs Anthony; Grucza Richard; Saccone Scott F; Krueger Robert; Neuman Rosalind; Howells William; Fisher Sherri; Fox Louis; Cloninger Robert; Dick Danielle M; Doheny Kimberly F; Edenberg Howard J; Goate Alison M; Hesselbrock Victor; Johnson Eric; Kramer John; Kuperman Samuel; Nurnberger John I Jr; Pugh Elizabeth; Schuckit Marc; Tischfield Jay; Rice John P; Bucholz Kathleen K; Bierut Laura J

来源：ADDICTION BIOLOGY, 2011, 16(3): 514-518.

DOI：10.1111/j.1369-1600.2010.00255.x

• Association
• cannabis dependence
• case-control
• DSM
• genomewide
• PLINK

Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.

• 出版日期2011-7