Antibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteria

作者：Wang Sin Ge; Chen Yen Chun^*; Chen Yu Chie^*

来源：Nanomedicine, 2018, 13(12): 1405-1416.

DOI：10.2217/nnm-2017-0380

• antibacterial agents
• gold nanoparticles
• multivalent interactions
• near infrared (NIR)
• photothermal
• vancomycin
• vancomycin-resistant Enterococci

Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15 degrees C under irradiation by a near-infrared laser (lambda = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.

• 出版日期2018-6