Antibacterial anthraquinone dimers from marine derived fungus Aspergillus sp

作者：Li, Jian Lin; Jiang, Xin; Liu, Xinpei; He, Caiwei; Di, Yuxin; Lu, Saijian; Huang, Huilian; Lin, Bin; Wang, Dong^*; Fan, Boyi^*

来源：Fitoterapia, 2019, 133: 1-4.

DOI：10.1016/j.fitote.2018.11.015

• Marine derived fungus
• Aspergillus versicolor
• Anthraquinone dimers
• Antibacterial
• Cytotoxicity

As a continue investigation of the bioactive secondary metabolites from marine derived fungi, two new anthraquinone dimers (1, 2), along with three known anthraquinones (3-5) and two known xanthones (6, 7) were isolated from the marine-derived fungus Aspergillus versicolor. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and comparison with reported ones. Among them, compounds 1 and 2 were identified as anthraquinone dimers which dimerized by a rare C-O-C ether linkage, and both of them showed selective antibacterial activity against Gram-positive Staphylococcus aureus; whilst compound 6 exhibited moderate cytotoxicity against human cancer cell lines.

• 出版日期2019-3
• 单位南通大学; 江西中医药大学; 沈阳药科大学