Asymmetric Michael addition of diphenylphosphine to beta,gamma-unsaturated alpha-keto esters catalyzed by a P-stereogenic pincer-Pd complex

作者：Xu, Yang; Yang, Zehua; Ding, Boqiang; Liu, Delong^*; Liu, Yangang; Sugiya, Masashi; Imamoto, Tsuneo; Zhang, Wanbin

来源：Tetrahedron, 2015, 71(38): 6832-6839.

DOI：10.1016/j.tet.2015.07.026

• Asymmetric Michael addition
• Diphenylphosphine
• beta,gamma-Unsaturated alpha-keto ester
• P-Stereogenic pincer-Pd complex

An asymmetric Michael addition of diphenylphosphine to (beta,gamma-unsaturated alpha-keto esters was developed using a P-stereogenic pincer-Pd complex as a catalyst. The corresponding hydrophosphination products were obtained in good yields (up to 94%) and with moderate to good enantioselectivities (up to 93% ee) under the optimum reaction conditions.

• 出版日期2015-9-23
• 单位上海交通大学