Delayed Effects of NMDA Receptor Antagonist MK-801 on Storage and Reconsolidation of Spatial Memory in Rats

作者：Storozheva Z I^*; Solovieva O A; Proshin A T; Sherstnev V V

来源：Bulletin of Experimental Biology and Medicine, 2012, 153(5): 605-608.

DOI：10.1007/s10517-012-1777-6

• glutamate NMDA glutamat receptors
• MK-801
• learning
• spatial memory
• rats

We studied the effects of NMDA receptor antagonist MK-801 on the storage and reconsolidation of spatial memory in Morris water maze in adult rats. MK-801 (50 mu g/kg) administered 24 h after the completion of training was shown to improve the resistance of spatial memory to spontaneous extinction, while reminder against the background of MK-801 suppresses its ameliorating effect on memory storage. The detected behavioral effects of MK-801 persisted over 60 days after administration and can be associated with its influence on coupled neurogenesis/apoptosis processes induced during memory trace formation in adult animals.

• 出版日期2012-9