Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest

作者:Cao Shugeng; Brodie Peggy J; Miller James S; Randrianaivo Richard; Ratovoson Fidy; Birkinshaw Chris; Andriantsiferana Rabodo; Rasamison Vincent E; Kingston David G I*
来源:Journal of Natural Products, 2007, 70(4): 679-681.
DOI:10.1021/np060627g

摘要

A bioassay-guided fractionation of the EtOH extract of the Madagascan plant Terminalia calcicola led to the isolation of two new cytotoxic xanthones, termicalcicolanone A (1) and termicalcicolanone B (2). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic data. Both compounds showed modest antiproliferative activity toward the A2780 human ovarian cancer cell line.

  • 出版日期2007-4