Acute Human Inkoo and Chatanga Virus Infections, Finland

作者：Putkuri Niina^*; Kantele Anu; Levanov Lev; Kivisto Ilkka; Brummer Korvenkontio Markus; Vaheri Antti; Vapalahti Olli

来源：Emerging Infectious Diseases, 2016, 22(5): 810-817.

DOI：10.3201/eid2205.151015

Inkoo virus (INKV) and Chatanga virus (CHATV), which are circulating in Finland, are mosquitoborne California serogroup orthobunyaviruses that have a high seroprevalence among humans. Worldwide, INKV infection has been poorly described, and CHATV infection has been unknown. Using serum samples collected in Finland from 7,961 patients suspected of having viral neurologic disease or Puumala virus infection during the summers of 2001-2013, we analyzed the samples to detect California serogroup infections. IgM seropositivity revealed 17 acute infections, and cross neutralization tests confirmed presence of INKV or CHATV infections. All children (<= 16 years of age) with INKV infection were hospitalized; adults were outpatients with mild disease, except for 1 who was hospitalized with CHATV infection. Symptoms included fever, influenza-like illness, nausea or vomiting, disorientation, nuchal rigidity, headache, drowsiness, and seizures. Although many INKV and CHATV infections appear to be subclinical, these viruses can cause more severe disease, especially in children.

• 出版日期2016-5