Association Between Interleukin-6 and Neurocognitive Performance as a Function of Self-Reported Lifetime Marijuana Use in a Community Based Sample of African American Adults

作者：Keen Larry II^*; Turner Arlener D

来源：Journal of the International Neuropsychological Society, 2014, 20(8): 773-783.

DOI：10.1017/S1355617714000691

• Proinflammatory cytokine
• Cannabis
• Executive function
• Psychomotor speed
• Inflammation
• Cognition

The purpose of the current study was to determine if self-reported lifetime marijuana use moderates the relationship between interleukin-6 (IL-6) and neurocognitive performance. Participants included 161 African American adults (50.3% women), with a mean age of 45.24 (SD = 11.34). Serum was drawn upon entry into the study and participants completed a demographic questionnaire, which included drug use history, and a battery of neuropsychological tests. Using multiple regression analyses and adjusting for demographic covariates, the interaction term comprised of IL-6 and self-reported lifetime marijuana use was significantly associated with poorer performance on the Written (beta = -.116; SE =.059; p = .049) and Oral trials (beta = -.143; SE = .062; p = .022) of the Symbol Digit Modalities Test, as well as the Trail Making Test trial A (beta = .157; SE = .071; p = .028). Current findings support previous literature, which presents the inverse relationship between IL-6 and neurocognitive dysfunction. The potential protective properties of marijuana use in African Americans, who are at increased risk for inflammatory diseases, are discussed. (JINS, 2014, 20, 773-783)

• 出版日期2014-9