Neuronal expression of fibroblast growth factor receptors in zebrafish

作者：Rohs Patricia; Ebert Alicia M; Zuba Ania; McFarlane Sarah^*

来源：Gene Expression Patterns, 2013, 13(8): 354-361.

DOI：10.1016/j.gep.2013.06.006

• mRNA expression
• Development
• Embryonic
• Danio rerio

Fibroblast growth factor (FGF) signaling is important for a host of developmental processes such as proliferation, differentiation, tissue patterning, and morphogenesis. In vertebrates, FGFs signal through a family of four fibroblast growth factor receptors (FGFR 1-4), one of which is duplicated in zebrafish (FGFR1). Here we report the mRNA expression of the five known zebrafish fibroblast growth factor receptors at five developmental time points (24, 36, 48, 60, and 72 h postfertilization), focusing on expression within the central nervous system. We show that the receptors have distinct and dynamic expression in the developing zebrafish brain, eye, inner ear, lateral line, and pharynx. In many cases, the expression patterns are similar to those of homologous FGFRs in mouse, chicken, amphibians, and other teleosts.

• 出版日期2013-12