Application of neutrophil/lymphocyte ratio in predicting coronary blood flow and mortality in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention

作者：Pan, Wei; Zhao, Deliang; Zhang, Canxiu; Li, Wenhua; Yu, Jiahui; Wang, Shu; Li, Zhuqin; Wang, Zhonghua; Sun, Xinyong; Liu, Hongwei; Sun, Yanming; Tian, Ye; Wang, Lanfeng^*

来源：Journal of Cardiology, 2015, 66(1-2): 9-14.

DOI：10.1016/j.jjcc.2014.10.014

• Neutrophil to lymphocyte ratio
• Coronary blood flow
• In-hospital mortality
• Long-term mortality
• Percutaneous coronary intervention

Background: To investigate the potential correlation of neutrophil/lymphocyte ratio (NLR) to coronary blood flow and in-hospital along with long-term mortality in patients with ST-elevation myocardial infarction (STEM!) undergoing percutaneous coronary intervention (PCI). @@@ Methods: In the current study, 636 consecutive patients with STEMI were recruited and stratified into three tertiles by NLRs upon admission (tertile I < 3.0, tertile II 3.0-6.40, tertile III > 6.40). The coronary blood flow was expressed by corrected TIMI frame count (CTFC). The in-hospital mortality and 12-month long follow-up data were collected. Receiver operating characteristic (ROC) curves were also constructed. @@@ Results: Our analysis demonstrated that NLR was positively correlated to CTFC and in-hospital mortality (r = 0.517, p < 0.001; r = 0.439, p < 0.001). In the multiple logistic regression analysis, NLR was testified as an independent risk factor for coronary blood flow after PCI and in-hospital mortality [odds ratio (OR) = 2.031, 95% confidence interval (Cl): 1.627-2.435, p < 0.001; OR 1.176, 95% CI: 1.025-1.351, p = 0.021]. During the 12-month follow-up, there were a total of 43 deaths and statistically significant increase in long-term mortality was observed in patients from tertile I to III (p = 0.005). In the ROC curves analysis, the area under the curve (AUC = 0.607,95% CI: 0.475-0.739, p = 0.253), with threshold value of 5.9 (sensitivity: 63.7%, specificity: 61.1%) for predicting in-hospital mortality. @@@ Conclusions: NLR, an indicator that can be tested in the laboratory with low cost and time consumption, is independently correlated to coronary blood flow and acts as an independent risk factor for in-hospital mortality in patients with STEM! undergoing PCI.

• 出版日期2015-7
• 单位哈尔滨医科大学