A novel method for similarity/dissimilarity analysis of protein sequences

作者：Mu, Zengchao; Wu, Jing; Zhang, Yusen^*

来源：Physica A: Statistical Mechanics and Its Applications , 2013, 392(24): 6361-6366.

DOI：10.1016/j.physa.2013.08.008

• Protein sequence
• Similarity
• Distance frequency matrix
• Phylogenetic tree

Sequence comparison is one of the major tasks in bioinformatics, which can be used to study structural and functional conservation, as well as evolutionary relations among the sequences. In this paper, we introduce the concept of distance frequency of amino acid pairs and propose a new numerical characterization of protein sequences, which converts any protein sequence into a distance frequency matrix. Using this distance frequency matrix, we can compare the similarity of protein sequences. In order to confirm the validity of our method, we test it with two experiments. The results show that our method is effective.

• 出版日期2013-12-15
• 单位山东大学