Nickel tetrazolato complexes synthesized by microwave irradiation: Catecholase like activity and interaction with biomolecules

作者：Malviya Novina; Mandal Poulami; Das Mriganka; Ganguly Rakesh; Mukhopadhyay Suman

来源：Journal of Coordination Chemistry, 2017, 70(2): 261-278.

DOI：10.1080/00958972.2016.1260121

• Nickel
• tetrazolato complexes
• protein binding
• catecholase activity

1,3-Dipolar cycloaddition between nickel-ligated azide in [NiL(N-3)][HL = 3-(2-diethylamino-ethylimino)-1-phenyl-butan-1-one] and two different organonitriles furnished two new square-planar complexes viz. [NiL(5-phenyltetrazolato)] and [NiL{5-(4-pyridyl)-tetrazolato}]. Both the complexes have been characterized by spectroscopic tools and single-crystal X-ray crystallography. Interaction with different biomolecules revealed that both complexes bind strongly to serum albumin proteins and show moderate catecholase-like activity by catalyzing the oxidation of 3,5-ditertbutylcatechol (3,5-DTBC). Identification of intermediates formed in catechol oxidation has been explored by ESI-MS spectrometry.

• 出版日期2017
• 单位南阳理工学院