A novel collagen film with micro-rough surface structure for corneal epithelial repair fabricated by freeze drying technique

作者：Liu, Yang; Ren, Li; Wang, Yingjun^*

来源：Applied Surface Science, 2014, 301(May.15): 396-400.

DOI：10.1016/j.apsusc.2014.02.089

• Cornea
• Collagen
• Film
• Rough surface

Corneal epithelial defect is a common disease and keratoplasty is a common treatment method. A collagen film with micro-rough surface was fabricated through a simple freeze drying technique in this study. Compared with the air-dried collagen film (AD-Col), this freeze-dried collagen film (FD-Col) has a more suitable water uptake capability (about 85.5%) and toughness performance. Both of the two films have good optical properties and the luminousness of them is higher than 80%. Besides, the adhesion and proliferation rate of human corneal epithelial cells on the micro-rough surface of FD-Col film is higher than that on the smooth surface of AD-Col film. The results indicate that this FD-Col film may have potential applications for corneal epithelial repair.

• 出版日期2014-5-15
• 单位华南理工大学