科研之友
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摘要
Among diseases associated with the inflammasome, monogenic autoinflammatory syndromes dominate in paediatric medicine. In contrast, in adults, the focus has shifted to very common diseases, where interleukin-1 (IL-1) release by the NLRP-3 inflammasome apparently plays an essential role. For one major example, uric acid crystals activate this pathway, and IL-1 blockade has been shown to be very effective for treating, but even more for preventing, gout attacks. Other crystals also have this potential, which does not only include the CPPD crystals of pseudogout, but also cholesterol deposits in atherosclerosis, for example, and for type II diabetes mellitus, first clinical trial results also showed an effect of IL-1 blockade.
- 出版日期2011-8
