Microbial Sensing by Toll Receptors A Historical Perspective

作者：Chtarbanova Stanislava; Imler Jean Luc^*

来源：Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, 31(8): 1734-1738.

DOI：10.1161/ATVBAHA.108.179523

• immune system
• macrophages
• receptors
• viruses

The family of Toll-like receptors plays an essential role in the induction of the immune response. These receptors sense the presence of microbial ligands and activate the nuclear factor-kappa B transcription factor. We review the key studies that led from the formulation of the concept of pattern recognition receptors to the characterization of Toll-like receptors, insisting on the important role played by the model organism Drosophila melanogaster and on the increasing evidence connecting these receptors to cardiovascular disease. (Arterioscler Thromb Vasc Biol. 2011; 31: 1734-1738.)

• 出版日期2011-8