A Preliminary Investigation of the Role of the Phenylalynine: Tyrosine Ratio in Children With Early and Continuously Treated Phenylketonuria: Toward Identification of "Safe" Levels

作者：Sharman Rachael^*; Sullivan Karen; Young Ross; McGill Jim

来源：Developmental Neuropsychology, 2010, 35(1): 57-65.

DOI：10.1080/87565640903325725

Children with early and continuously treated phenylketonuria (ECT-PKU) remain at risk of developing executive EF) deficits. There is some evidence that a high phenylalanine to tyrosine ratio (phe:tyr) is more strongly associated with impaired EF development than high phenylalanine alone. This study examined EF in a sample of 11 adolescents against concurrent and historical levels of phenylalanine, phe:tyr, and tyrosine. Lifetime measures of phe: tyr were more strongly associated with EF than phenylalanine-only measures. Children with a lifetime phe: tyr less than 6 demonstrated normal EF, whereas children who had a lifetime phe: tyr above 6, on average, demonstrated clinically impaired EF.

• 出版日期2010