科研之友
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摘要
Cows with left displaced abomasum (LDA), a costly disease occurring primarily in multiparous dairy cows during early lactation, have been reported to have 40% lower circulating concentrations of vitamin E. It is unknown, however, whether the lower circulating alpha-tocopherol concentrations precede LDA or remain after LDA. Using a nested case-control design, blood samples taken at d -21, -14, -7, -3, -1, 0, 1, 3, 7, 14, 21, 28, 35, 42, and 49 postpartum from 7 multiparous Holstein cows diagnosed with LDA between d 6 and 32 postpartum and 10 healthy Holstein cows from the same herd were analyzed for serum concentrations of alpha-tocopherol and indicators of energy and nutrient status and inflammation. In addition to indicators of negative energy balance and inflammation, lower serum alpha-tocopherol concentrations preceded LDA and persisted after LDA correction. At the last blood sampling before LDA diagnosis, cows had serum alpha-tocopherol concentrations 45% lower (5.0 +/- 0.9 vs. 9.1 +/- 0.9 mu M) and alpha-tocopherol to cholesterol molar ratios 39% lower (1.90 +/- 0.19 vs. 3.09 +/- 0.26) than those of healthy cows. Serum alpha-tocopherol concentrations remained lower (%26lt;10 vs. similar to 15 mu M) up to d 49 postpartum in cows that had LDA. These findings indicate that lower serum alpha-tocopherol concentrations are a potential early indicator for the development of LDA in multiparous cows.
- 出版日期2013-5
