An unexpected presentation: minimal change disease in an adult with treatment-naive hepatitis C

作者：Stokes Audrey L; Alhamad Tarek^*; Abendroth Catherine S; Farag Hosam A; Verma Navin

来源：International Urology and Nephrology, 2013, 45(6): 1801-1804.

DOI：10.1007/s11255-012-0285-y

• Acute renal failure
• Hepatitis C
• Minimal change disease
• Nephrotic syndrome

Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a middle-aged African-American male who presented with the nephrotic syndrome and acute renal failure and was concomitantly diagnosed with a new hepatitis C infection. He also had a history of urethral strictures with potential reflux nephropathy, which-in combination with his African-American race-also made focal segmental glomerulosclerosis a diagnostic possibility. Full laboratory evaluation did not distinguish the cause of his massive proteinuria; subsequent renal biopsy ultimately revealed minimal change disease. A full course of high-dose steroids eventually reduced his proteinuria, after which his renal failure resolved as well without need for hemodialysis.

• 出版日期2013-12