Association between retinal microcirculation and aortic stiffness in hypertensive patients

作者：Katsi Vasiliki^*; Vlachopoulos Charalambos; Souretis Georgios; Baou Katerina; Dagalaki Ioanna; Alexopoulos Nikolaos; Tousoulis Dimitris; Hatziyianni Amalia; Stefanadis Christodoulos; Kallikazaros Ioannis

来源：International Journal of Cardiology, 2012, 157(3): 370-373.

DOI：10.1016/j.ijcard.2010.12.074

• Arterial stiffness
• Fundoscopy
• Hypertension
• Hypertensive retinopathy
• Pulse wave velocity

Background: The fundoscopic examination of hypertensive patients, an established hypertension-related target organ damage, tends to be underutilized in clinical practice. We sought to investigate the relationship between retinal alterations and aortic stiffness, an independent predictor of cardiovascular morbidity and mortality.
Methods: Our population consisted of 197 consecutive essential hypertensive patients (age 60 +/- 13 years, 115 females) without overt cardiovascular disease. All subjects underwent fundoscopy examination and were distributed to four groups according to Scheie's grading system. Aortic stiffness was evaluated by carotidfemoral pulse wave velocity with a validated device (Complior).
Results: The four groups (Scheie's grades 0-3: including 24, 75, 74, 24 patients respectively) did not differ with regard to age, gender and their metabolic profile. Patients with higher Scheie's category had higher values of pulse wave velocity (8.2 +/- 1.5, 8.9 +/- 1.7, 9.3 +/- 1.8, 9.8 +/- 2.1 m/s respectively, p=0.001). Multivariable regression analysis showed that age, fundus classification and systolic arterial pressure were independent determinants of pulse wave velocity.
Conclusion: Hypertensive subjects exhibit a progressive stiffening of the aorta in parallel with the progression of retinal alterations according to Scheie's scale. Further studies are needed to clarify involved pathophysiological mechanisms and explore possible causal relationships.

• 出版日期2012-6-14